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Important Questions for "Immunology":

[1]

  1. What is antibody diversity? Discuss the genetic and molecular mechanisms responsible for generation of antibody diversity.
  2. Differentiate between MHC class I, MHC class II and MHC class III complexes with suitable diagrams.
  3. Discuss the mechanism of clonal selection of B cells.

[2]

  1. Describe the structure of Immunoglobulin and write the features of various types of Immunoglobulins with suitable diagrams.
  2. Explain antigen-antibody cell-mediated cytotoxicity. What are the important roles of cytokines?
  3. How are monoclonal antibodies produced? Write their application in the field of diagnostics and therapeutics.

[3]

  1. Write short notes on: (a) Pernicious anaemia (b) Rheumatoid Arthritis (c) Hashimoto's thyroiditis.
  2. Write short notes on: (a) MHC complex (b) Abnormal Immunoglobulin (c) Type IV Hypersensitivity Reaction (d) Acquired immunity.
  3. What is immunoelectrophoresis? What is the meaning of the terms RIA and IRMA?

[4]

  1. What is Immunoelectrophoresis? What is the meaning of the terms IRMA and ELISA?
  2. Give a concise account of the nature of vaccines. Discuss the role of biotechnology in the development of new methods for vaccine production.
  3. What is humoral immunity? How is it different from cell-mediated immunity? Explain.

[5]

  1. Write a note on RIA.
  2. Write a note on the organization of class I and II MHC genes.
  3. Write a note on macrophages.

[6]

  1. What are Immunoglobulins? Provide a detailed account of antibody IgG with diagrams.
  2. Write an essay on antigen-antibody reaction.
  3. What is vaccination? How many types of vaccines exist across generations?

[7]

  1. What are the uses of recombinant DNA technology in human welfare?
  2. What are monoclonal antibodies? Describe the method of production and use of monoclonal antibodies.
  3. Describe the structure and functioning of cosmid and phagemid vectors.

[8]

  1. Explain the concept of DNA recombinant technology.
  2. Explain the role of Biotechnology in food processing.
  3. How to measure Immune Responses in Animal Models?

[9]

  1. What are RAM and ROM?
  2. Differentiate between cloning vector and expression vector.
  3. Write a short note on Karyotyping.

[10]

  1. What are auto immune diseases? OR Calculate median of the given data: 9, 6, 7, 8, 8, 9, 6, 5, 4, 7
  2. Explain the role of Genetic Engineering in agriculture OR Explain the importance of Vaccination in Human health
  3. What is Biotechnology? Discuss the role of Biotechnology in pharmaceuticals

[11]

  1. Compare monoclonal and hybrid antibodies.
  2. Comment upon gas phase for cell cultures.
  3. What is immunogenicity? Explain four properties of immunogens that determine immunogenicity.

[12]

  1. Explain the concept of hapten.
  2. Describe the five structures of IgG and its diversity.
  3. Write notes on: ELISA, MHC.

[13]

  1. What are Cytokines? Give a suitable example.
  2. What is tissue and organ culture? Summarize its methods.
  3. Write short notes on any two of the following: In-vitro fertilization, Transgenic Animal, ELISA.

[14]

  1. Difference between Humoral and cell-mediated immunity.
  2. Write a note on Antigen-Antibody interaction.
  3. Write short notes on: Ethical and social issues related to human cloning, B lymphocytes.

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